Melanoma
نویسندگان
چکیده
The management of cutaneous malignant melanoma has been transformed by the development effective medical treatment for what was previously a chemo-resistant disease. primary stage I and II disease remains complete excision with wider being performed in most cases assuming morbidity is not excessive. A series randomized trials have demonstrated that historical very wide margins did improve outcome introduced significant morbidity. Much more conservative are now advised. synchronous sentinel node biopsy patients greater than 1 mm Breslow thickness to determine whether should receive adjuvant systemic therapy. Complete nodal dissection only who present palpable Genetic analysis mutation BRAF gene be all III IV as this will respond therapies targeting signalling pathway. Stage metastatic amenable either immunotherapy or BRAF-targeted Surgery still an important role play symptomatic localized refractory these therapies.
منابع مشابه
Primary duodenal malignant melanoma: A case report
Background: Melanoma is a neoplasm derived commonly from melanocytic cells of skin. Although coetaneous presentation of malignant melanoma is easily recognizable, the presentation of melanoma in other organs is so confusing. In particular, when it metastasizes to other organs, many bizarre figures and unusual organs may be involved. In this report, we present a case of primary duodenal malignan...
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ژورنال
عنوان ژورنال: Surgery (Oxford)
سال: 2022
ISSN: ['0263-9319', '1878-1764']
DOI: https://doi.org/10.1016/j.mpsur.2021.11.011